Exploring the Role of Phytoconstituents for Endocrine Disorder: A Review

The endocrine system consists of various glands responsible for secreting hormones that regulate metabolism, growth, reproduction, and other physiological processes. Disruptions in this system, termed endocrine disorders, are linked to numerous health issues, such as obesity, diabetes, cardiovascular diseases, and metabolic syndromes. Moreover, the significance of factors such as life stage, gender and dietary habits in influencing health risks associated with endocrine disruption cannot be overstated. Synthetic medications for these conditions often have adverse side effects like hypoglycemia and heart complications, highlighting the need for alternative treatments. Herbal and natural remedies have shown promise in managing these disorders due to their lower toxicity and minimal side effects. Phytochemicals and poly-herbal therapies are emerging as effective strategies for addressing endocrine and metabolic disorders, influencing molecular targets like AMP-Activated Protein Kinase (AMPK) and Nuclear factor erythroid-2- related factor (Nrf2). Specific disorders such as diabetes, Addison’s disease, and hyperthyroidism are characterized by hormone imbalances, with molecular mechanisms involving insulin resistance, cortisol dysregulation, and thyroid dysfunction. Additionally, the role of factors such as life stage, gender, and dietary habits in modulating endocrine disruption-associated health risks is crucial. Natural products, including flavonoids, catechins, resveratrol, and terpenes, are being explored for their therapeutic potential in regulating hormone levels and improving metabolic health.