ArticlesAbstractPharmacognosy Research,2018,10,2,213-217.DOI:10.4103/pr.pr_118_17Published:April 2018Type:Original ArticleAuthors:Anil T. Pawar, Gayatri D. Gaikwad, and Bhanudas S. Kuchekar Author(s) affiliations:Anil T Pawar, Gayatri D Gaikwad, Bhanudas S Kuchekar Department of Pharmacology, MAEER's Maharashtra Institute of Pharmacy, Pune, Maharashtra, INDIA. Abstract:Background: Hedyotis corymbosa Linn. (family: Rubiaceae) has been used in the Indian indigenous system of medicine, Ayurveda, for treatment of various health aliments. Objectives: The present study was undertaken to evaluate the antidepressant activity of methanolic extract of whole plant of H. corymbosa (MHC) in olfactory bulbectomy rats. Materials and Methods: MHC was prepared and standardized to gallic acid by high‑performance thin‑layer chromatograph method. Effects of 14 days oral treatment of fluoxetine (30 mg/kg) and three doses of MHC (50, 100, and 200 mg/kg) were evaluated on olfactory bulbectomy (OBX)‑induced alterations in behavioral and biochemical parameters in rats. Results: MHC treatment reversed the OBX‑induced behavioral abnormalities such as increased exploratory activity in open‑field paradigm and decreased feeding latency time in novelty‑suppressed feeding test. Serum cortisol levels were restored near to normal by the MHC treatment. Further, treatment of MHC prevented the OBX‑induced decline of brain levels of serotonin and nor‑adrenaline in dose‑dependent manner. Conclusion: MHC prevents behavioral and neurochemical changes in OBX‑induced depression in rats. These results demonstrate the antidepressant effect of H. corymbosa and support its folklore claim. Keywords:Cortisol, Depression, Hedyotis corymbosa, Olfactory bulbectomyView:PDF (901.4 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images High‑performance thin layer chromatograph densitogram of (a) gallic acid and (b) methanolic extract of Hedyotis corymbosa standardized to gallic acid (peak no. 1) scanned at 278 nm (AT COLUMN WIDTH) KeywordsCortisolDepressionHedyotis corymbosaOlfactory bulbectomy ‹ Evaluation of Protective Effects of Hydroalcoholic Extract of Cassia fistula Linn. Pod on Pancreas in Streptozotocin‑induced Diabetic Rats up Anti‑inflammatory Effect of Procumbenoside B from Justicia spicigera on Lipopolysaccharide‑Stimulated RAW 264.7 Macrophages and Zebrafish Model ›