Effect of Musa sapientum Stem Extract on Animal Models of Depression

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Abstract
Pharmacognosy Research,2016,8,4,249-252.
Published:August 2016
Type:Original Article
Authors:
Author(s) affiliations:

Aditya J Reddy1, Shailendra S Handu1, Ashok Kumar Dubey1, Pramod Kumari Mediratta1, Rimi Shukla2, Qazi Mushtaq Ahmed1

1Department of Pharmacology, SMS&R, Sharda University, Greater Noida, NCR, Uttar Pradesh, INDIA.

2Department of Biochemistry, University College of Medical Sciences, New Delhi, INDIA.

Abstract:

Background: Musa sapientum, the banana plant, has shown to possess antioxidant activity in previous studies. Oxidative stress has been linked to the pathogenesis of major depressive disorder (MDD) with evidence of increased serum levels of oxidative stress biomarkers in MDD patients. Objective: The present study aimed to evaluate the antidepressant activity of M. sapientum stem extract (MSSE) in experimental models in mice. Materials and Methods: Forced swim test (FST) and tail suspension test (TST) were carried out in five different groups (n = 6/ group) of mice. The vehicle, standard drug, and the three test groups were orally administered distilled water (10 mL/kg), fluoxetine (25 mg/kg), and incremental doses of 25, 50, and 100 mg of MSSE, respectively, 45 min prior to the experiment. Results: On FST, the duration of immobility in control group, which was 161.5 ± 6.78 (in seconds, mean ± standard error of mean [SEM]), decreased to 149.33 ± 2.70 (25 mg/kg MSSE), 120.17 ± 8.35 (50 mg/kg MSSE), and 45.17 ± 4.11 (100 mg/kg MSSE) in the treated groups. On TST, the duration of immobility in control group, which was 173.83 ± 12.65 (mean ± SEM), decreased to 163.17 ± 6.91 (25 mg/kg MSSE), 139.0 ± 5.9 (50 mg/kg MSSE), and 124.0 ± 4.42 (100 mg/kg MSSE) in the treated groups. The difference in the duration of immobility was statistically significant at middle and higher doses, i.e. 50 and 100 mg/kg MSSE (P < 0.05) respectively, when compared with the control group in both the tests. Conclusion: A significant antidepressant‑like activity was found in MSSE, which could be a potential natural compound for use in depression.

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Effect of Musa sapientum stem extract on the duration of immobility on forced swim test. **P < 0.001 as compared to control group

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