ArticlesAbstractPharmacognosy Research,2014,6,1, 42-45.DOI:10.4103/0974-8490.122916Published:December,2013Type:Original ArticleAuthors:Hebbani Nagarajappa Shivaprasad, Sushma Gopalakrishna, Bhanumathy Mariyanna, Midhun Thekkoot, Roopa Reddy, and Boreddy Shivanandappa Tippeswamy Author(s) affiliations:Hebbani Nagarajappa Shivaprasad1, Sushma Gopalakrishna1, Bhanumathy Mariyanna1, Midhun Thekkoot1, Roopa Reddy2, Boreddy Shivanandappa Tippeswamy2 1R&D Centre, Olive Lifesciences Pvt. Ltd., Karnataka, India. 2Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka, India. Abstract:Background: Obesity is a metabolic disorder that can lead to adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance and also increases the risk of coronary heart disease, ischemic stroke and type 2 diabetes mellitus. This study was designed to determine the effect of Coleus forskohlii on obesity and associated metabolic changes in rats fed with cafeteria diet. Objective: The aim of this study was to evaluate antiobesogenic and metabolic benefits of C. forskohlii in cafeteria diet induced obesity rat model. Materials and Methods: Rats were randomly divided into five groups of six animals in each group and as follows: Normal pellet diet group; cafeteria diet group; cafeteria diet followed by 50 mg/kg/d Coleus forskohlii extract (CFE), 100 mg/kg/d CFE and 45 mg/kg/d orlistat groups, respectively. Indicators of obesity such as food intake, body weight and alteration in serum lipid profiles were studied. Results: Feeding of cafeteria diet induced obesity in rats. Administration of CFE significantly halted increase in food intake and weight gain associated with cafeteria diet. Development of dyslipidemia was also significantly inhibited. Conclusion: The observed effects validate that supplementation of CFE with cafeteria diet could curb the appetite and mitigate the development of dyslipidemia. Keywords:Appetite, Cafeteria diet, cholesterol, Coleus forskohlii, Lipid profileView:PDF (442.24 KB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Effect of Coleus forskohliiextract on cafeteria diet-induced obesity in rats KeywordsAppetiteCafeteria dietcholesterolColeus forskohliiLipid profile ‹ Comparative Assessment on In vitro Antioxidant Activities of Ethanol Extracts of Averrhoa bilimbi , Gymnema Sylvestre and Capsicum Frutescens up Ethanolic Extracts of Alstonia Scholaris and Bacopa Monniera Possess Neuroleptic Activity Due to Anti-dopaminergic Effect ›