Benincasa cerifera Ameliorates Renal Ischemia/Reperfusion Injury in Hyperlipidemic Rat

Bhalodia Y.S; Patel N.J; Patel R.K; Vaghasiya J.D; Jivani N.P; Sheth N.R

Benincasa cerifera Ameliorates Renal Ischemia/Reperfusion Injury in Hyperlipidemic Rat

Articles

Abstract

Pharmacognosy Research,2009,1,6,406-409.

DOI:

Published:January 2010

Type:Original Article

Authors:

Author(s) affiliations:

Bhalodia Y.S *¹, Patel N.J², Patel R.K², Vaghasiya J.D¹, Jivani N.P¹, Sheth N.R³

¹Smt.R.B.Patel Mahila Pharmacy College, S.N.D.T Women's University, Atkot-360040. Dist: Rajkot. Gujarat (INDIA.

²Department of Pharmacology, S.K.Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva-382711. Gujarat INDIA.

³Department of Pharmaceutical sciences, Saurashtra University, Rajkot-360005. Gujarat INDIA.

Abstract:

To investigate protective effect of Benincasa cerifera (BC) against kidney injury induced by Ischemia/Reperfusion (I/R) in hyperlipidemic (HC) rats. Hyperlipidemia was developed by cholesterol diet (2% cholesterol and 20 % coconut oil) feeding for 3 weeks. At the end of 3^rdweek, renal ischemia was induced by both renal arteries occlusion for 60 min followed 24 h of reperfusion. Methanolic extract of Benincasa cerifera (500 mg/kg/day) was administered orally 7 days before induction of ischemia. Benincasa cerifera treatment reversed all antioxidant parameters like superoxide dismutase (SOD), reduced glutathione (GSH) and malondialdehyde (MDA) contents as well serum creatinine and blood urea nitrogen (BUN) levels. This data conclude the renoprotective activity of Benincasa cerifera against renal damage induced by ischemia/reperfusion injury in hyperlipidemic rat.

Keywords:Benincasa cerifera, cholesterol, Oxidative stress, Renal ischemia/reperfusion injury