Biological and Chemical Study of Cleome paradoxa B.Br.

Essam Abdel-Sattar; Azza R. Abd El-Monem; Amany A. Sleem

Biological and Chemical Study of Cleome paradoxa B.Br.

Articles

Abstract

Pharmacognosy Research,2009,1,4,175-178.

DOI:

Published:January 2010

Type:Original Article

Authors:

Author(s) affiliations:

Essam Abdel-Sattar¹, Azza R Abd El-Monem², Amany A Sleem³

¹Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, SAUDI ARABIA.

²Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, EGYPT.

³Pharmacology Department, National Research Centre, Giza 12622, EGYPT.

Abstract:

The methanolic extract of Cleome paradoxa B.Br. and its different fractions (viz. hexane, chloroform, ethyl acetate and n-butanol) were tested for their antidiabetic activities. The ethyl acetate and hexane fractions exhibited the highest activities, which further subjected to chemical investigation. This study resulted in isolation of two compounds from the ethyl acetate fraction and three compounds from the hexane fraction. These compounds were identified using different spectroscopic methods as quercetin, quercetin-3-O-β-D-glucopyranoside (isoquercetrin), α-amyrin, sitgmasterol and sitgmasterol-3-O-β-D-glucpyranoside. The major compound isolated from ethyl acetate fraction, isoquercetrin, was assessed for its antidiabetic activity.

Keywords:Antidaiabetic, Antihyperglycemic, Cleome paradoxa, Isoquercetrin