New Triterpenoid Acyl Derivatives and Biological Study of Manilkara Zapota (L.) Van Royen Fruits

Nesrin M Fayek; Azza R Abdel Monem; Mohamed Y Mossa,; Meselhy R Meselhy

New Triterpenoid Acyl Derivatives and Biological Study of Manilkara Zapota (L.) Van Royen Fruits

Articles

Abstract

Pharmacognosy Research,2013,5,2,55-59.

DOI:10.4103/0974-8490.110505

Published:April 2013

Type:Review Article

Authors:

Author(s) affiliations:

Nesrin M Fayek, Azza R Abdel Monem, Mohamed Y Mossa, Meselhy R Meselhy

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

Abstract:

β-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, ¹ H-NMR, ¹³ C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.

Keywords:4-caffeoylquinic acid, Antihyperglycemic, Antioxidant, Hypocholesterolemic, Lupeol-3-acetate, Manilkara zapota, β-amyrin-3-(3′-dimethyl)butyrate