Solanum Trilobatum in the Management of Atopy: Through Inhibition of Mast Cell Degranulation and Moderation of Release of Interleukins

MS Ranjith; A J A Ranjitsingh; S Gokul Shankar; GS Vijayalaksmi; K Deepa; K Babu; Harcharan Singh Sidhu

Solanum Trilobatum in the Management of Atopy: Through Inhibition of Mast Cell Degranulation and Moderation of Release of Interleukins

Articles

Abstract

Pharmacognosy Research,2010,2,1,10-14.

DOI:10.4103/0974-8490.60581

Published:March 2010

Type:Original Article

Authors:

Author(s) affiliations:

MS Ranjith¹, A. J. A. Ranjitsingh², S Gokul Shankar¹, GS Vijayalaksmi³, K Deepa⁴, K Babu⁵, Harcharan Singh Sidhu¹

¹Faculty of Medicine, Microbiology Unit, AIMST University, Kedah, Malaysia.

²Department of Advanced Zoology and Biotechnology, Sri Paramakalyani College, Alwarkurichi, India.

³Sri Paramakalyani Center for Environmental Sciences, M. S. University, Tirunelveli, India.

⁴Faculty of Medicine, 3Anatomy Unit, AIMST University, Kedah, Malaysia.

⁵R and D Center, Cholayil Private Limited, Chennai, India

Abstract:

Solanum trilobatum is a widely used plant in the Indian indigenous systems of medicine. It is mainly used in the treatment of respiratory diseases like bronchial asthma. In our present study, we report that the aqueous and alcoholic extracts of S. trilobatum exhibited inhibition of mast cell degranulation. Further, aqueous and alcoholic extracts of S. trilobatum significantly decreased the release of IL1α and increased the release of IL8 from the cultured keratinocytes. Oral administration of the aqueous and alcoholic extracts of S. trilobatum stabilized mast cells in experimental rats.

Keywords:Histamine, Immunomodulation, Interleukin, Mast cell, Medicinal plants, Solanum trilobatum