Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats

Marie Claire Tchamadeu; Paul Désiré Djomeni Dzeufiet; Nelly Blaes; Jean-Pierre Girolami; Pierre Kamtchouing; Théophile Dimo

Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats

Articles

Abstract

Pharmacognosy Research,2017,9,1,80-86.

DOI:10.4103/0974-8490.199767

Published:February 2017

Type:Original Article

Authors:

Author(s) affiliations:

Marie Claire Tchamadeu¹, Paul Désiré Djomeni Dzeufiet², Nelly Blaes³, Jean-Pierre Girolami³, Pierre Kamtchouing², Théophile Dimo²

¹Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.

²Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, CAMEROON.

³INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.

Abstract:

Aim of the Study: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH₂Cl₂/CH₃OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. Materials and Methods: Streptozotocin (STZ)‑induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH₂Cl₂/CH₃OH plant extracts of P. soyauxii at various doses (38–300 mg/kg) in a single administration. In addition, STZ‑induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment. Results: Acute administration of aqueous and CH₂Cl₂/ CH₃OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P < 0.05 to P < 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH₂Cl₂/CH₃OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover, P. soyauxii also significantly (P < 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/ aspartate aminotransferase) elevations. Conclusion: P. soyauxii Taub stem bark extracts have possible value for antidiabetic oral medication.