02735nas a2200265 4500008004100000245017100041210006900212260001800281300001000299490000600309520182300315653002202138653002202160653001702182653003002199653000902229653001902238100002902257700003102286700001702317700002602334700002402360700002102384856006402405 2017 eng d00aAntidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats0 aAntidiabetic Effects of Aqueous and DichloromethaneMethanol Stem cFebruary 2017 a80-860 v93 a

Aim of the Study: The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxii Taub in normal and diabetic rats. Materials and Methods: Streptozotocin (STZ)‑induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxii at various doses (38–300 mg/kg) in a single administration. In addition, STZ‑induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment. Results: Acute administration of aqueous and CH2Cl2/ CH3OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P < 0.05 to P < 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH2Cl2/CH3OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover, P. soyauxii also significantly (P < 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/ aspartate aminotransferase) elevations. Conclusion: P. soyauxii Taub stem bark extracts have possible value for antidiabetic oral medication.

10aAntihyperglycemic10aDiabetes mellitus10aPhytotherapy10aPterocarpus soyauxii Taub10aRats10aStreptozotocin1 aTchamadeu, Marie, Claire1 aDzeufiet, Paul, Désiré D1 aBlaes, Nelly1 aGirolami, Jean-Pierre1 aKamtchouing, Pierre1 aDimo, Théophile uhttps://phcogres.com/article/2017/9/1/1041030974-8490199767