Background: the presence of phytochemical constituents has been reported from species of the Compositae Caesalpiniaceae. Objectives: The present study was designed to determine the bioactive compounds in the heartwood of hydroethanolic extract. Materials and Methods: Phytochemical screening of the entire herb of Caesalpinia sappan revealed the presence of some bioactive components. Gas Chromatography-Mass Spectrometry (GC-MS) analysis of the heartwood of hydroethanolic extract was performed on GC-MS equipment. Results: The phytochemical tests showed the presence of alkaloids, alkaloids, cardiac glycosides, flavonoids, phenols, phlorotannins, reducing sugars, saponins, steroids, tannins, terpenoids, volatile oils, carbohydrates, protein/amino acids in the hydroethanolic extract of Caesalpinia sappan. The GC-MS analysis has shown the presence of different phytochemical compounds in the hydroethanolic extract of Caesalpinia sappan. A total of 38 compounds were identified. The major components are 9-octadecenoic acid, Oleic Acid, Sarcosine and Dinonanoin. Conclusion: from the results, it is evident that Caesalpinia sappan contains various photo components and is recommended as a plant of phytopharmaceutical importance.