Background: Homeopathy is a complementary alternative medicine system which was introduced by Samuel Hahnemann in Europe in the last part of the eighteenth century. In homeopathy, drugs are obtained from various source materials such as plants, chemicals, minerals, and animals. However, plants are the major source and about 65% of medicines homeopathic medicines obtained from plants (HPI Vol. I to XI). Authentication and identification of genuine drugs is major concern for manufacturing units/industries. The present study will help to add key parameters in the identification of drugs. Objective: The objective of this study is to characterize the foliar epidermal characteristics of selected plants used in homeopathy. Materials and Methods: The foliar epidermal studies of Aegle marmelos (L.) Corrêa, Bryophyllum calycinum Salisb., Cannabis indica Lam., Cephalandra indica (Wight and Arn.) Naudin, Eucalyptus globulus Labill., Gaultheria procumbens L., Gymnema sylvestre (Retz.) R. Br. ex Sm., Justicia adhatoda L., Nyctanthes arbor-tristis L., and Ricinus communis L. Results: The study showed various characteristic features such as presence or absence of hairs or trichomes, trichomes if present were uni to multicellular, types and size of stomata, stomatal index on dorsal and ventral sides, vein-islet per mm2, vein termination per mm2, and presence or absence of idioblasts, etc. All these features will help in the identification and characterization of medicinal plants. Conclusion: The study revealed that the diversity of foliar characters of the leaf was varying from plant to plant and this variation may be a valuable tool for the authentication and identification of drug.