ArticlesAbstractPharmacognosy Research,2017,9,3,247-252.DOI:10.4103/pr.pr_8_17Published:July 2017Type:Original ArticleAuthors:Subramani Parasuraman, Khor Ming Zhen, Urmila Banik, and Parayil Varghese Christapher Author(s) affiliations:Subramani Parasuraman1, Khor Ming Zhen1, Urmila Banik2, Parayil Varghese Christapher1 1Unit of Pharmacology, Faculty of Pharmacy, AIMST University, Kedah, MALAYSIA. 2Department of Pathology, Faculty of Medicine, AIMST University, Kedah, MALAYSIA. Abstract:Objective: To evaluate the effect of curcumin on olanzapine‑induced obesity in rats. Materials and Methods: Sprague‑Dawley (SD) rats were used for experiments. The animals were divided into six groups, namely, normal control, olanzapine control, betahistine (10 mg/kg), and curcumin 50, 100, and 200 mg/kg treated groups. Except the normal control group, all other animals were administered with olanzapine 4 mg/kg intraperitoneally to induce obesity. The drugs were administered once daily, per oral for 28 days. During the experiment, body weight changes and behavior alterations were monitored at regular intervals. At the end of the experiment, blood sample was collected from all the experimental animals for biochemical analysis. Part of the liver and kidney tissues was harvested from the sacrificed animals and preserved in neutral formalin for histopathological studies. Results: Curcumin showed a significant reduction in olanzapine‑induced body weight gain on the rats and improved the locomotor effects. The effect of curcumin on olanzapine‑induced body weight gain is not comparable with that of betahistine. Conclusion: This study has shown metabolic alteration effect of curcumin on olanzapine, an antipsychotic drug, treated SD rats. Keywords:Betahistine, Curcumin, Obesity, OlanzapineView:PDF (1.33 MB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images Percentage changes in body weight alterations of experimental animals. All the values are mean ± standard error of the mean (n = 6) KeywordsBetahistineCurcuminObesityOlanzapine ‹ Antioxidant and Antiproliferative Activity of Asparagopsis taxiformis up Spectrophotometric Quantification of Flavonoids in Herbal Material, Crude Extract, and Fractions from Leaves of Eugenia uniflora Linn ›