ArticlesAbstractPharmacognosy Research,2015,7,5s,26-33.DOI:10.4103/0974-8490.150508Published:June 2015Type:Original ArticleAuthors:Solomon E Owumi, Abiodun C Oloidi, Cinzia O Oloye, Oludare O Oladeji, Moses O Obadare, and Oyeronke A Odunola Author(s) affiliations:Solomon E Owumi, Abiodun C Oloidi, Cinzia O Oloye, Oludare O Oladeji, Moses O Obadare, Oyeronke A Odunola Department of Biochemistry, Cancer Research and Molecular Biology Unit, Faculty of Basic Medical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria. Abstract:Objectives: The potential toxicity of Keayodendron bridelioides (KB), Monodora myristica (MM) were examined, and phytoprotection of MM and KB stemming from their phytochemical contents against sodium arsenite (SA) induced clastogenicity in Wister's rat. Materials and Methods: Dose range studies of KB in rats, genotoxicity of MM and KB by SOS-inductive respomse were investigated using E. coli PQ37. Male rats were exposed to varying concentrations of MM, KB over a five week period to evaluate MM and KB phytoprotectives properties were also evaluated against sodium arsenite induced micronucleated erythrocytes, hepatotoxicity and sperm quality and morphology. Results: In contrast to KB, MM induced micronuclei formation in rat erythrocytes, MM and KB were however not genotoxic. MM, SA alone and in combination were hepatotoxic, characterized by elevated hepatic transaminases. Hepatoxicity were ameliorated by co-administration of KB (P < 0.05). MM and KB did not induce changes in semen morphology (P > 0.05); but decreased sperm count and motility (P < 0.05). Extracts exhibited anti-clastogenic (KB > MM), hepatoprotective (KB > MM) activities and maintained semen viability against SA treatment. Conclusion: Finding applications as herbal medicinal and food components KB and MM may be useful in mitigating the effect of toxicants in biological systems susceptible to oxidative damage. Keywords:Keayodendron bridelioides, Micronuclei and phytoprotection, Monodora myristica genotoxicityView:PDF (1.56 MB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images SOS induction factor of Keayodendron bridelioides (KB) and Monodora myristica (MM) extracts on Escherichia coli PQ37 bacteria- SOS-chromotest (a and b) KeywordsKeayodendron bridelioidesMonodora myristica genotoxicityMicronuclei and phytoprotection ‹ Antidermatophytic Activity of Mikania micrantha Kunth: An Invasive Weed up Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats ›