Chemical Constituents from the Leaves of Euphorbia ammak Growing in Saudi Arabia

Essam Abdel‑Sattar; Dina Abou‑Hussein; Frank Petereit

Chemical Constituents from the Leaves of Euphorbia ammak Growing in Saudi Arabia

Articles

Abstract

Pharmacognosy Research,2015,7,1,14-17.

DOI:10.4103/0974-8490.147136

Published:December 2014

Type:Original Article

Authors:

Author(s) affiliations:

Essam Abdel-Sattar¹, Dina Abou-Hussein², Frank Petereit³

¹Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.

²Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

³University of Münster, Institute of Pharmaceutical Biology and Phytochemistry, Hittorfstraße 56, D 48149 Münster, German.

Abstract:

Investigation of the chloroform extract of Euphorbia ammak leaves led to the isolation of three compounds: euphol (1), α‑glutinol (2) and stigmasterol (3) Their structures were elucidated by 1D and 2D NMR, as well as by comparison with the reported data. Compounds 1‑3 exhibited cytotoxicity in vitro against human cervical adenocarcinoma (Hela), among which, compound 1 showed the best activity.

Keywords:Cervical adenocarcinoma, Euphol, Euphorbia ammak.