ArticlesAbstractPharmacognosy Research,2017,9,1,21-26.DOI:10.4103/0974-8490.199770Published:February 2017Type:Original ArticleAuthors:GM Gururaja, Deepak Mundkinajeddu, A Senthil Kumar, Shekhar Michael Dethe, J Joshua Allan, and Amit Agarwal Author(s) affiliations:GM Gururaja1, Deepak Mundkinajeddu2, A Senthil Kumar2, Shekhar Michael Dethe2, J Joshua Allan2, Amit Agarwal2 1Research Scholar, Manipal University, Manipal; Natural Remedies R and D Centre, Bengaluru, Karnataka, INDiA. 2Natural Remedies R and D Centre, Bengaluru, Karnataka, INDIA. Abstract:Introduction: Cholesterol lowering activity of Mangifera indica L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined. Materials and Methods: The present study involved evaluation of cholesterol lowering potential of methanol extract of M. indica leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-β-D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography. Results and Discussion: Significant cholesterol lowering activity was observed with methanol extract of M. indica leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-β-D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract. Conclusions: The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels. Keywords:Hypercholesterolemia, Mangifera indica, Mangiferin, Mango leavesView:PDF (1.3 MB) PDF Thumbnails Document Outline Search Document Find Toggle Sidebar Previous Next Page: Fullscreen Print Download Current View Zoom Out Zoom In Automatic Zoom Actual Size Fit Page Full Width 50% 75% 100% 125% 150% 200% More Information Less Information Close Click here to download the PDF file. Images High-performance liquid chromatography chromatograms overlay of standards and Mangifera indica leaf methanol extract KeywordsHypercholesterolemiaMangifera indicaMangiferinMango leaves ‹ The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitro Release, and Antiproliferative Activity of Thymoquinone Drug up Chronic Intake of Green Propolis Negatively Affecting the Rat Testis ›