%0 Journal Article %J Pharmacognosy Research %D 2013 %T Anti-ulcer and Ulcer Healing Potentials of Musa Sapientum Peel Extract in the Laboratory Rodents %A Samuel Adetunji Onasanwo %A Benjamin Obukowho Emikpe %A Austin Azubuike Ajah %A Taiwo Olayemi Elufioye %K Anti-ulcer %K Musa sapientum %K Peptic Ulcer %K Ulcer Healing %X

Background: This study investigated the anti-ulcer and ulcer healing potentials of the methanol extract of Musa sapientum peel in the laboratory rats. Materials and Methods: Methanol extract of the peels on Musa sapientum (MEMS) was evaluated for its anti-ulcer using alcohol-induced, aspirin-induced, and pyloric ligation-induced models, and for its ulcer healing employing acetic acid-induced ulcer models in rats. Results: The findings from this experiment showed that MEMS (50, 100 and 200 mg/kg, b.w.) anti-ulcer and ulcer healing activity (P ≤ 0.05) is dose-dependent. Also, MEMS exhibited healing of the ulcer base in all the treated groups when compared with the control group. Conclusion: The outcomes of this experiment revealed that the anti-ulcer effect of MEMS may be due to its anti-secretory and cyto-protective activity. The healing of the ulcer base might not be unconnected with basic fibroblast growth factors responsible for epithelial regeneration.

%B Pharmacognosy Research %V 5 %P 173-178 %8 May 2013 %G eng %N 3 %9 Original Article %& 173 %R 10.4103/0974-8490.112423