TY - JOUR T1 - Chemical Constituents and Bioactivities of Malabaila suaveolens JF - Pharmacognosy Research Y1 - 2009 A1 - Nassar Mahmoud I A1 - Aboutabl El-Sayed A A1 - Maklad Yousreya A A1 - El-Khrisy Ezzel-Din A A1 - Osman Abeer F KW - Bioactivity. KW - Coumarins KW - Flavonoids KW - Malabaila suaveolens AB -

Volatile oil components, fatty acids, β-amyrin, and sterols were identified in the n-hexane extract of Malabaila suaveolens Coss. fruits. Angelicin, 4,7,9-trimethyl psoralen, isopimpinellin and umbelliferone were isolated from the dichloromethane extract of the plant. 5-Hydroxy 7, 3`, 4`-trimethoxyflavone, apigenin and its 7-O-β-D-glucopyranoside were isolated from the ethyl acetate extract. From the methanol extract, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7-O-rutinoside, and 6-hydroxyapigenin 7-O-β-D-glucopyranoside were isolated. Toxicity study of n-hexane, dichloromethane, ethyl acetate extract and methanolic extracts of the plant proved that it is relatively nontoxic. The tested extracts showed significant analgesic and anti-inflammatory effects as compared with control groups and reference drugs. Also, the tested extracts showed significant antioxidant activity as compared with reference.

VL - 1 IS - 6 ER -