TY - JOUR T1 - Anticonvulsant and Anxiolytic Evaluation of Leaf Extracts of Ocimum gratissimum, a Culinary Herb JF - Pharmacognosy Research Y1 - 2010 A1 - CO Okoli A1 - AC Ezike A1 - OC Agwagah A1 - PA Akah KW - Anticonvulsant KW - Anxiolytic KW - Ocimum gratissimum KW - Open field AB -

Anticonvulsant and anxiolytic activities of leaf extracts and fraction of Ocimum gratissimum L. (Lamiaceae) were studied using seizures induced by pentylenetetrazol and open-field tests in mice. The results showed that the extracts and fraction increased the latency of tonic and tonic-clonic seizures and death and elicited 50% protection against mortality. In the open-field test, the extracts and fraction decreased the frequency of line crossing, center square entries, rearing against a wall and grooming, whereas grooming duration and freezing frequency and duration were increased. Acute toxicity test in mice gave an oral LD 50 greater than 5000 mg/kg for the methanol extract. These findings suggest that extracts of this plant possess anticonvulsant and anxiolytic-like properties.

VL - 2 IS - 1 ER -