TY - JOUR T1 - Chemical Composition, Antibacterial and Antifungal Activities of Essential Oil from Cordia Verbenacea DC Leaves JF - Pharmacognosy Research Y1 - 2012 A1 - Fabiola F. G. Rodrigues A1 - Liana G. S. Oliveira A1 - Fábio F. G. Rodrigues A1 - Manuele E. Saraiva A1 - Sheyla C. X. Almeida A1 - Mario E. S. Cabral A1 - Adriana R. Campos A1 - Jose Galberto M. Costa KW - Aminoglycosides KW - Antimicrobial activity KW - Cordia verbenacea KW - Essential oil. AB -

Background: Cordia verbenacea is a Brazilian coastal shrub popularly known as “erva baleeira”. The essential oil from fresh leaves was obtained by hydrodistillation and analyzed by CG/MS. The main components were identified as β-caryophyllene (25.4%), bicyclogermacrene (11.3%), δ-cadinene (9.%) and α-pinene (9.5%). In this study, the antimicrobial activity of Cordia verbenacea was evaluated. Materials and Methods: The minimal inhibitory concentration (MIC) of the essential oil was obtained using the broth microdilution assay (from 512 to 8 μg/ml). Results: The results showed that the essential oil presented fungistatic activity against Candida albicans and Candida krusei and antibacterial activity against Gram-positive strains (Staphylococcus aureus and Bacillus cereus) and against multiresistant Gram-negative (Escherichia coli 27), in all tests the MIC was 64 µg/ml. When the essential oil was associated to aminoglycosides (subinhibitory concentrations, MIC/8), a synergic and antagonic activity was verified. The synergic effect was observed to the amikacin association (MIC reduction from 256 mlto 64 µg/ml) in all strains tested. Conclusion: The essential oil of Cordia verbenacea influences the activity of antibiotics and may be used as an adjuvant in antibiotic therapy against respiratory tract bacterial pathogens.

VL - 4 IS - 3 ER -