TY - JOUR T1 - Phytochemical and Pharmacological Screening of Begonia grandis Dryand JF - Pharmacognosy Research Y1 - 2020 A1 - Srinivasarao Pendy A1 - Krishna Nallamothu A1 - Ganapaty Seru A1 - Sunitha Katta A1 - Sumanta Mondal KW - Antioxidant KW - Begonia grandis KW - Begoniaceae KW - Ethnomedicinal KW - Hepatoprotective KW - Silymarin AB -

Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl4-induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.

VL - 12 IS - 4 ER -