02127nas a2200229 4500008004100000245008300041210006900124260001700193300001200210490000600222520141700228653003101645653002001676653002101696653001401717100001801731700002001749700002101769700001901790700002501809856006301834 2010 eng d00aAnti-inflammatory Activity of Aqueous extract of Mirabilis jalapa Linn. Leaves0 aAntiinflammatory Activity of Aqueous extract of Mirabilis jalapa cJanuary 2011 a364-3670 v23 a

Background: The objective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL) (Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin. Methods: Aqueous extract of the leaves was prepared by cold maceration. Results: The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P < 0.05) inhibition of paw oedema, 37.5% and 54.0% on 4 th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9% and 43.0% on 4 th day at the doses of 200 and 400 mg/kg, respectively. Conclusion: The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.

10aanti-inflammatory activity10aAqueous extract10aMirabilis jalapa10aPaw edema1 aSingh, Manjit1 aKumar, Vijender1 aSingh, Ishpinder1 aGauttam, Vinod1 aKalia, Ajudhia, Nath uhttps://phcogres.com/article/2010/2/6/1041030974-849075456