01757nas a2200193   4500008004100000245011400041210006900155260001800224300001200242490000600254520115500260653001701415653001901432653001501451653001101466100001801477700001901495856004901514       2009                        eng d00aAntioxidative Effect of Trichosanthes tricuspidata Root Extract on Sildenafil Induced Migraine in Albino Mice0 aAntioxidative Effect of Trichosanthes tricuspidata Root Extract   cJanuary 2010   a402-4050 v13 a<p class="rtejustify">Migraine is considered a neurovascular disease involving the dilatation of cerebral arteries. Because of their dual role in modulating neuronal and vascular events, neuropeptides have been implied to be of importance in migraine pathophysiology. It is a highly prevalent disorder which manifests clinically as moderate to severe or severe headache attacks with frequent frontotemporal unilateral location and associated symptoms. The disability of migraine results in considerable economic and social losses .Nitric oxide, a short lived vasodilator and weak oxygen radical has been implicated in the genesis of migraine headaches. Hence the role of all enzymic and non enzymic antioxidants becomes in evitable in the treatment of migraine. <em>Trichosanthes tricuspidata’s</em> (red apple gourd) antioxidant effect was tested over Sildenafil induced migraine in female albino mice. The levels of antioxidant enzymes such as super oxide dismutase (SOD), lipid peroxidase(LPO), catalase(CAT) and glutahione peroxidase(GPx) were more promising in the treatment group fed with the root extract of Trichosanthes tricuspidata.</p>
10aNitric oxide10aOxygen radical10aSildenafil10aStress1 aP, Nithiya, .1 aMohan, Karthik  uhttps://phcogres.com/article/2009/1/6/nil-11