01777nas a2200205 4500008004100000245009200041210006900133260001800202300001200220490000600232520105600238653014001294100001601434700001101450700001601461700001601477700001701493700001301510856004801523 2009 eng d00aAntifungal activity of Tabernaemontana stapfiana Britten (Apocynaceae) Organic Extracts0 aAntifungal activity of Tabernaemontana stapfiana Britten Apocyna cJanuary 2010  a387-3910 v13 a

The methanol and successive (hexane, dichlroromethane, ethyl acetate and methanol) extracts of leaves, fruits, root and stem barks of Tabernaemontana stapfiana Britten were investigated for antifungal activity against four fungi; Candida albicans, Cryptococcus neoformans, Microsporum gypseum and Trichophyton mentagrophytes. The extracts of the different plant parts showed varied activities against the tested fungi with the stem and root barks showing significant antifungal activities. The minimum inhibitory concentrations (MICs) of methanol and sequential extracts ranged between 31.25 and 8000 μg/ml while the minimum fungicidal concentrations (MFCs) ranged between 125 and 8000 μg/ml. Among the test microorganisms, Candida albicans was the most susceptible with the lowest MIC of 31.25 μg/ml followed by Cryptococcus neoformans with an MIC of 62.25 μg/ml. These results show that it is possible to find antifungal compounds in the extracts of T. stapfiana.

10aTabernaemontana stapfiana Britten; Apocynaceae; Antifungal activity; Minimum inhibitory concentration; Minimum fungicidal concentration1 aE.K, Ruttoh1 aC, Bii1 aP.K., Tarus1 aA, Machocho1 aL.K., Karimi1 aP, Okemo uhttps://phcogres.com/article/2009/1/6/nil-8