02273nas a2200265 4500008004100000245009800041210006900139260001800208300001200226490000600238520151300244653001401757653001201771653001701783653002301800653001601823653001501839100001901854700002401873700001401897700001201911700001401923700002201937856004801959 2009 eng d00aEffect of Bark Extract and Gum Exudate of Commiphora Caudata on Aspirin Induced Ulcer in Rats0 aEffect of Bark Extract and Gum Exudate of Commiphora Caudata on  cJanuary 2010  a375-3800 v13 a

Commiphora caudata is used in Indian folk medicine as an antiulcerogenic agent. Despite of its promising use, there has been no scientific report present regarding its antiulcer activity. Therefore, this study was designed to evaluate the antiulcer activity of bark extract and gum exudate of commiphora caudata on aspirin induced ulcer in rats. Acute toxicity study was performed and 200 mg/kg was selected as an effective dose. Four groups of Albino Swiss rats were included in this study. Aspirin suspended in 0.5 % carboxymethyl cellulose (CMC) was given orally to group 1 rats as a negative control group. Group 2 and group 3 animals received methanolic extract and gum exudate of commiphora caudata respectively. Sucralfate was given orally to group 4 animals as a positive control. The methanolic extract of commiphora caudata has been found to reduce total acidity as much as by sucralfate. However, it has not changed the fluid secretion. The gum preparation not only reduced the total acidity but also considerably reduce the gastric fluid secretion. In case of ulcer score sucralfate, methanolic extract and the gum have produced the low ulcer score compared to aspirin. Increased gastric mucosal protective mechanism by bark extract and gum exudate is probably due to the presence of some active principles present in the plant. However, further investigations are required to elucidate their exact mechanism of anti-ulcer activity.

10aAntiulcer10aAspirin10aBark extract10aCommiphora caudata10aGum exudate10aSucralfate1 aR, Nanthakumar1 aS, Stephen, Ambrose1 aE, Sriram1 aG, Babu1 aK, Chitra1 aC, Uma, maheswara uhttps://phcogres.com/article/2009/1/6/nil-6