02112nas a2200217 4500008004100000245011100041210006900152260001800221300001200239490000600251520143500257653002201692653001601714653001501730653002601745653002001771653002001791100001901811700001601830856004801846 2009 eng d00aScreening of Psidium guajava Leaf Extracts for Antistress Activity in Different Experimental Animal Models0 aScreening of Psidium guajava Leaf Extracts for Antistress Activi cJanuary 2010  a359-3660 v13 a

Ethanolic extract of leaves of Psidium guajava was investigated on anoxia stress tolerance test in Swiss mice. The animals were also subjected to acute physical stress (swimming endurance test) and acute heat induced stress to gauge the antistress potential of the extract. Further to evaluate the antistress activity of Psidium guajava in chronic stress condition, fresh Wistar rats were subjected to cold restraint stress (4° for 2 h) for 10 days. Stimulation of hypothalamus pituitary adrenal axis in stressful condition alters plasma glucose, triglyceride, cholesterol, BUN and corticosterone levels. There is also alteration in the blood cell counts. Pretreatment with the extract significantly (P<0.001) ameliorated the stress-induced variations in these biochemical levels and blood cell counts in both acute and chronic stress models. The extract treated animals showed increase in swimming endurance time and increase in anoxia tolerance time in physical and anoxia stress models respectively. Treatment groups also reverted back increase in liver, adrenal gland weights and atrophy of spleen caused by cold chronic stress and swimming endurance stress models. The results indicate that ethanolic extract of Psidium guajava has significant adaptogenic activity against a variety of biochemical and physiological perturbations in different stress models.

10aAcute heat stress10aAdaptogenic10aAntistress10aCold restraint stress10aPsidium guajava10aSwimming stress1 aB.V.S, Lakshmi1 aM, Sudhakar uhttps://phcogres.com/article/2009/1/6/nil-4