01754nas a2200253 4500008004100000245016400041210006900205260001800274300001200292490000600304520093500310653002201245653001601267653002201283653002501305653001901330100002001349700002001369700001301389700001701402700001701419700001601436856004801452 2009 eng d00aAntihyperglycemic and Antioxidant Activities of Active Fraction from the Aqueous Extract of Momordica cymbalaria fruits in Streptozotocin Induced Diabetic Rats0 aAntihyperglycemic and Antioxidant Activities of Active Fraction cJanuary 2010 a352-3580 v13 a
The methanolic supernatant fraction (MSF) of the aqueous extract of Momordica cymbalaria fruits when given to streptozotocin (STZ) induced diabetic rats showed a significant reduction (65.9%, P<0.001) in fasting blood glucose levels at a dose of 0.5g/kg.b.w. These results were compared to that of glibenclamide, an oral hypoglycemic agent. The active MSF exhibited a dose dependent scavenging activity against 2, 2-diphenly-1-picrylhydrazyl (DPPH) radicals and nitric oxide radicals with an IC50 value of 42.5 and 157.2μg/ml, respectively. Further, the MSF had relatively lower reducing power, compared to that of ascorbic acid. The total phenolic content of the fraction was found to be 132mg/gm of dry fraction. In conclusion, MSF possess antihyperglycemic and antioxidant properties, which could be due to the presence of steroidal glycosides or phenolic compounds.
10aAntihyperglycemic10aAntioxidant10aDiabetes mellitus10aMomordica cymbalaria10aStreptozotocin1 aM.D, Rajasekhar1 aK, Ramesh, Babu1 aK, Vinay1 aM.R, Sampath1 aS.K, Sameena1 aCh, Apparao uhttps://phcogres.com/article/2009/1/6/nil-3