02009nas a2200241 4500008004100000245011800041210006900159260001900228300001200247490000600259520124200265653001601507653001701523653001601540653001701556100002501573700002201598700002101620700002201641700002001663700002101683856006301704 2011 eng d00aAntioxidant, cytotoxic, antitumor, and protective DNA damage metabolites from the red sea brown alga Sargassum sp0 aAntioxidant cytotoxic antitumor and protective DNA damage metabo cSeptember 2011 a160-1650 v33 a

Background: Macroalgae can be viewed as a potential antioxidant and anti-inflammatory sources owing to their capability of producing compounds for its protection from environmental factors such as heat, pollution, stress, oxygen concentration, and UV radiations. Objective: To isolate major compounds which are mainly responsible for the pharmacological activity of brown alga under investigation, Sargassum sp. Materials and Methods: Algal material was air dried, extracted with a mixture of organic solvents, and fractionated with different adsorbents. The structures of obtained pure compounds were elucidated with different spectroscopic techniques, and two pure materials were tested for protection of DNA from damage, antioxidant, antitumor, and cytotoxicity. Results: Four pure compounds were obtained, of which fucosterol (1) and fucoxanthin (4) were tested; it was found that fucoxanthin has strong antioxidant and cytotoxicity against breast cancer (MCF-7) with IC 50 = 11.5 ΅g/ml. Conclusion: The naturally highly conjugated safe compound fucoxanthin could be used as antioxidant and as an antitumor compound.

10aAntioxidant10acytotoxicity10aFucoxanthin10aSargassum sp1 aAyyad, Seif-Eldin, N1 aEzmirly, Saleh, T1 aBasaif, Salim, A1 aAlarif, Walied, M1 aBadria, Adel, F1 aBadria, Farid, A uhttps://phcogres.com/article/2011/3/3/1041030974-849085000