02216nas a2200217 4500008004100000245007100041210006900112260001800181300001200199490000600211520156800217653001801785653002201803653001101825653001401836653002101850100001801871700002801889700001801917856006301935 2014 eng d00aAcetylcholine and Memory-Enhancing Activity of Ficus racemosa Bark0 aAcetylcholine and MemoryEnhancing Activity of Ficus racemosa Bar cNovember,2011 a246-2490 v33 a

Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder resulting in dementia and enhancement of acetylcholine (Ach) levels in brain using acetylcholinesterase inhibitors is one of the most important approaches for the treatment of AD. Methods: In this study, aqueous extract of Ficus racemosa Linn. (Moraceae) bark having anti-infl ammatory, antioxidant, and anticholinesterase activity was evaluated for its ability to enhance Ach levels, and to ascertain its antidementia activity in rats. This work was carried out under the assumption that the F. racemosa extract may show combination of actions which could be beneficial in the treatment of AD, such as neuroprotection, attributed to antioxidant and anti-infl ammatory property and may elevate levels of Ach like Ficus hispida extract reported earlier. Results: Administration of the extract at two levels viz., 250 and 500 mg/kg signifi cantly raised (P ≤ 0.05) Ach levels in hippocampi of rats compared to control. The percentage enhancement in Ach levels was found to be 22% and 38%, respectively. Further, the extract at both dosage levels elicited signifi cant reduction (P ≤ 0.05) in transfer latency on elevated plus-maze, which was used as an exteroceptive behavioral model to evaluate memory in rats. Conclusion: It is inferred that it would be worthwhile to explore the potential of F. racemosa in the management of Alzheimer disease.

10aAcetylcholine10aAlzheimer disease10aMemory10aPlus-maze10aTransfer latency1 aAhmed, Faiyaz1 aChandra, J., N. Narendr1 aManjunath, S. uhttps://phcogres.com/article/2014/3/4/1041030974-849089744