02537nas a2200217 4500008004100000245006900041210006800110260001800178300001200196490000600208520187300214653001702087653001902104653001902123653001902142100001502161700002802176700002002204700003202224856006302256 2011 eng d00aIndigenous Anti-ulcer Activity of Musa Sapientum on Peptic Ulcer0 aIndigenous Antiulcer Activity of Musa Sapientum on Peptic Ulcer cNovember,2011 a232-2380 v33 a

Background: Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical evaluation of antiulcer drugs showed tolerance, incidence of relapses and sideeffects that make their efficacy arguable. An indigenous drug like Musa sapientum possessing fewer side-effects is the major thrust area of present day research, aiming at a better and safer approach for the management of PUD. Material and Methods: The unripe plantain bananas (Musa sapientum) were shade-dried, powdered and used for phytochemical analysis and as antiulcer drug. In our present study Group I rats served as control and were treated with saline, Group II was indomethacin-induced ulcerated rats, Group III received aqueous extract of Musa sapientum along with indomethacin and Group IV received esomeprazole along with indomethacin for 21 days. The anti-ulcerogenic activity was investigated by performing hematological, mucosal, antioxidant profile in comparison with the standard drug esomeprazole. Results: Our findings from High - Performance Thin Layer Chromatography (HPTLC) analysis showed that Musa sapientum has an active compound a monomeric flavonoid (leucocyanidin) with anti-ulcerogenic activity. Results were expressed as mean ± SD. All our results are in congruous with the results of standard drug esomeprazole. Conclusion: It could be clearly concluded that administration of the aqueous extract of Musa sapientum at the dose used in this study tends to ameliorate ulcers. Its use in indigenous medicine should be scientifically scrutinized with further research.

10aEsomeprazole10aGastric mucosa10aLleucocyanidin10aMusa sapientum1 aPrabha, P.1 aKarpagam, Thirunethiran1 aVaralakshmi, B.1 aPackiavathy, Sohna, Chandra uhttps://phcogres.com/article/2011/3/4/1041030974-849089742