02393nas a2200277 4500008004100000245012500041210006900166260001900235300001200254490000600266520152100272653002001793653001301813653001801826653002101844653000901865653002201874653002301896100003201919700001801951700003101969700001602000700002002016700001602036856006302052 2010 eng d00aAntidiabetic Activity and Phytochemical Screening of Crude extract of Stevia rebaudiana in Alloxan-induced Diabetic Rats0 aAntidiabetic Activity and Phytochemical Screening of Crude extra cSeptember 2010 a258-2630 v23 a

Background: Stevia rebaudiana regulates blood sugar, prevents hypertension and tooth decay. Other studies have shown that it has antibacterial as well as antiviral property. Methods: Preliminary phytochemical screening of aqueous, ether and methanolic extracts of S. rebaudiana was done. Acute and sub-acute toxicity were conducted on twenty four Albino rats, divided into one control (Group I) and three treatment groups viz. aqueous extract (Group II), ether extract (Group III) and methanolic extract (Group IV). For the study of antidiabetic effect of S. rebaudiana rats were divided into seven groups (n=6). Diabetes was induced by a single dose of 5% alloxan monohydrate (125 mg/kg, i.p.) after 24 hour fasting.Blood samples were analysed on day 0, 1, 5, 7, 14 and 28. Results: Phytochemical tests showed presence of different kinds of phyto-constituents in aqueous, ether and methanol extract of Stevia rebaudiana leaves. Daily single dose (2.0 g/kg) administration of aqueous extract (A.E.) , ether extract (E.E.) and methanol extract (M.E.) for 28 days of S. rebaudiana could not show any significant change in ALT and AST levels in rats. Blood sugar level was found to be decreased on day 28 in groups of rats treated with A.E., E.E. and M.E. of S. rebaudiana. Conclusion: The extracts of Stevioside rebaudiana could decrease the blood glucose level in diabetic rats in time dependent manner.

10aAqueous extract10aDiabetes10aEther extract10aMethanol extract10aRats10aStevia rebaudiana10aSub-acute toxicity1 aKujur, Vishakha, Singh R. S1 aRam, Mahendra1 aYadava, Harlokesh, Narayan1 aSingh, K, K1 aKumari, Suruchi1 aRoy, B., K. uhttps://phcogres.com/article/2010/2/4/1041030974-849069128