01720nas a2200205 4500008004100000245008000041210006900121260001800190300001200208490000600220520108500226653001801311653002601329653002601355653002601381100001701407700002601424700001601450856004801466 2009 eng d00aAntimicrobial and Resistance Modulatory Activities of Corynanthe pachyceras0 aAntimicrobial and Resistance Modulatory Activities of Corynanthe cJanuary 2010  a280-2840 v13 a

s part of the project to identify plant natural products which modulate bacterial multidrug resistance (MDR) the methanol extract of Corynanthe pachyceras (Rubiaceae) K. Schum., were tested for in vitro antibacterial and resistance modifying activities against different bacterial strains including resistant staphylococcus SA1199B, RN4220 and XU212 possessing the Tet(K), Msr(A), and Nor(A) multidrug resistance efflux mechanisms respectively. Using the Micro-well dilution method the MIC of the stem bark extract ranged between 128-512μg/ml against the selected bacteria used. At 10μg/ml, none of the different extracts displayed any antibacterial action but in combination with tetracycline, erythromycin and norfloxacin, the stem bark extract displayed a 2-fold, 4-fold and 8-fold potentiation of activities of these antibiotics against XU212, SA1199B and RN4220 possessing the Tet(K) [tetracycline resistant], Nor(A) [norfloxacin resistant] and Msr(A) [macrolide resistant] transporters respectively.

10aAntibacterial10aCorynanthe pachyceras10aResistance modulators10aStaphyloccocus aureus1 aFrancis, Adu1 aYao, Gbedema, Stephen1 aKofi, Annan uhttps://phcogres.com/article/2009/1/5/nil-6