02395nas a2200217 4500008004100000245011400041210006900155260001600224300001200240490000600252520169700258653001201955653003601967653001302003100001602016700002502032700001702057700001802074700002102092856006402113 2014 eng d00aEffect of Licorice Versus Bismuth on Eradication of Helicobacter Pylori in Patients with Peptic Ulcer Disease0 aEffect of Licorice Versus Bismuth on Eradication of Helicobacter cAugust,2014 a341-3440 v63 a

Background: Different therapeutic regimens were used for eradication of Helicobacter pylori, based on the cost, effectiveness and patient's compliance. The aim of this study was the evaluation of licorice compared with bismuth in quadruple regimen on eradication of H. pylori in patients with peptic ulcer disease (PUD). Materials and Methods: In a double-blind clinical trial study, 60 patients with PUD and positive rapid urease test were enrolled. The patients were randomly allocated into two equal groups. In first group, licorice, amoxicillin, metronidazole and omeprazole and in the second (control) group, bismuth subsalicylate, amoxicillin, metronidazole and omeprazole were prescribed respectively, and 4 weeks after treatment, in order to evaluate H. pylori eradication, urea breath test was done in all patients. The outcome of the study was the preference usage of licorice as an effective medication for H. pylori eradication. Results: Mean age of the patients in the control and case groups were 40.8 ± 15.5 and 42.2 ± 15.8 years, respectively (P = 0.726). Seventeen (56.7%) patients in control group and 16 (53.3%) in the case group were female (P = 0.795). Both groups were similar based on frequency of gastric or duodenal ulcer. Response to treatment were seen in 20 (67%) and 17 (57%) patients of case and control groups, respectively (P > 0.05). Conclusion: Our study showed that licorice is as effective as bismuth in H. pylori eradication; therefore, in patients whom bismuth is contraindicated, licorice can be used safely instead.

10aBismuth10aHelicobacter pylori eradication10aLicorice1 aMomeni, Ali1 aRahimian, Ghorbanali1 aKiasi, Abass1 aAmiri, Masoud1 aKheiri, Soleiman uhttps://phcogres.com/article/2014/6/4/1041030974-8490138289