02450nas a2200205 4500008004100000245008300041210006900124260001600193300001200209490000600221520182400227653001202051653001902063653001502082653001802097100002602115700002302141700001602164856006402180 2014 eng d00aNovel strategies for optimized delivery of select components of Allium sativum0 aNovel strategies for optimized delivery of select components of  cAugust,2014 a334-3400 v63 a

Background: Garlic (Allium sativum) has been known to exhibit a wide range of pharmacological activities which are attributed mainly to the organosulfur compounds present in it. Allicin and garlic oil, components obtained from garlic, have been explored and found to be biologically active on various fronts. Allicin is known to have major stability issues due to rapid degradation even at low temperatures, whereas garlic oil, being lipophilic, shows poor bioavailability after oral administration. Objective: To develop novel strategies for optimum delivery of allicin and garlic oil so as to achieve effective availability in the physiological system. Materials and Methods: Garlic cloves were lyophilized to obtain allicin-releasing garlic powder (ARGP). This powder was analyzed spectrophotometrically and was used to formulate buccal tablets. Garlic oil was obtained by hydrodistillation of garlic cloves and analyzed by gas chromatography. Self-nanoemulsifying systems (SNS) containing garlic oil were prepared using suitable surfactants and cosurfactants. The SNS were adsorbed on Aerosil 200 and filled in hard gelatin capsules. Both the formulations were suitably evaluated. Results: Buccal tablets containing ARGP showed satisfactory physical parameters as well as in vitro drug release, mucoadhesive strength, moisture uptake capacity and drug content. Evaluation of capsules containing SNS of garlic oil also gave satisfactory results. The adsorbed SNS when dispersed in water formed nanoemulsions. Conclusion: Buccal tablets as well as capsules containing garlic oil SNS provide promising strategies to overcome the difficulties associated with formulation of allicin and garlic oil.

10aAllicin10aBuccal tablets10aGarlic oil10aNanoemulsions1 aPhadatare, Avinash, G1 aViswanathan, Vivek1 aMukne, Alka uhttps://phcogres.com/article/2014/6/4/1041030974-8490138288