02100nas a2200205 4500008004100000245013500041210006900176260001400245300001200259490000600271520140700277653001701684653002601701653001801727653002101745100001801766700001901784700002801803856006301831 2010 eng d00aEffect of Celastrus paniculatus seed oil (Jyothismati oil) on Acute and Chronic Immobilization Stress Induced In swiss Albino Mice0 aEffect of Celastrus paniculatus seed oil Jyothismati oil on Acut cJuly 2010 a169-1740 v23 a

Stress alters the homeostasis and is produced by several factors. Immobilization stress induced due to reduced floor area provided for the mobility results in the imbalance of oxidant and antioxidant status. The modern computer savvy world decreases human mobility in the working environment, leading to the formation of oxygen free radicals and if left untreated might result in severe health problems like hypertension, cardiovascular disease, premature aging and brain dysfunction. Hence, modern medicines rely upon the medicinal plants for some drugs with zero side effects. In this context, Jyothismati oil (JO), extracted from Celastrus paniculatus seeds, was used to treat acute and chronic immobilization induced experimentally. C. paniculatus plant is considered to be rich in antioxidant content and so the seed oil extract's efficacy was tested against immobilization stress in albino mice. The animals were kept in a restrainer for short and long durations, grouped separately and fed with the drug. Animals were sacrificed and the samples were analyzed. The antioxidant enzyme levels of the animals regained and markedly increased in the acute and chronic immobilized groups, respectively. The results suggested that the extract of C. paniculatus seed was highly efficacious in reducing the stress induced by least mobility for hours.

10aAntioxidants10aCelastrus paniculatus10aFree radicals10aOxidative damage1 aLekha, George1 aMohan, Karthik1 aSamy, Irudhaya, Arockia uhttps://phcogres.com/article/2010/2/3/1041030974-849065512