02665nas a2200253 4500008004100000245009700041210006900138260001600207300001200223490000600235520184500241653003102086653001702117653003102134653002402165653002602189100003002215700001202245700001602257700003602273700001902309700001902328856006402347 2014 eng d00aEvaluation of the Efficacy of 2% Curcumin Gel in the Treatment of Experimental Periodontitis0 aEvaluation of the Efficacy of 2 Curcumin Gel in the Treatment of cAugust,2014 a326-3330 v63 a

Context: Local drug delivery (LDD) systems have been proposed for the treatment of periodontitis. Curcumin could be a suitable agent as LDD for the treatment of periodontitis. Aim: To formulate, evaluate the anti-inflammatory activity and to assess the duration of the action and the efficacy of 2% curcumin gel in the treatment of experimental periodontitis in Wistar albino rat model. Settings and Design: Twenty-one Wistar albino rats were randomly assigned to three groups. Periodontitis was induced using ligature model. Group 1: Control; group 2: Plain gel, and group 3: 2% curcumin gel. Materials and Methods: About 2% curcumin gel was prepared. The anti-inflammatory activity and duration of action was assessed. Silk ligature 5-0 was used to induce periodontitis. Gingival index (GI) and probing pocket depth (PPD) were measured. Treatment was done. The rats were sacrificed. Morphometric analysis was performed using stereomicroscope and ImageJ software. Statistical Analysis Used: Analysis of variance followed by Bonferroni's test, Wilcoxon's test for inter-group comparison, Mann-Whitney test for P value computation was used. The observations are mean ± standard deviation and standard error of the mean. P < 0.01 when compared to control was considered as statistically significant. Results: About 2% curcumin gel showed 42.98% inhibition of edema and peak activity was noted at 24 hr. There was statistically significant change in the GI and PPD. Morphometric analysis did not show any significant difference between groups. No toxic effects were seen on oral administration of 2000 mg/kg of curcumin. Conclusions: About 2% curcumin gel was effective in the treatment of experimental periodontitis.

10aanti-inflammatory activity10aCurcumin gel10aExperimental periodontitis10aLocal drug delivery10aMorphometric analysis1 aHosadurga, Rajesh, Ramesh1 aRao, SN1 aJose, Jobin1 aRompicharla, Narayana, Charyulu1 aShakil, Moidin1 aShashidhara, R uhttps://phcogres.com/article/2014/6/4/1041030974-8490138287