02225nas a2200241 4500008004100000245009800041210007100139260001600210300001200226490000600238520143200244653001601676653002501692653002101717653002101738100002601759700003101785700002701816700002101843700003701864700001801901856006401919 2014 eng d00aAmeliorative Effect of Phytocee™ Cool Against Carbon Tetrachloride-induced Oxidative Stress0 aAmeliorative Effect of Phytocee™ Cool Against Carbon Tetrachlori cAugust,2014 a320-3250 v63 a

Background: Antioxidants from natural sources have a major role in reversing the effects of oxidative stress and promoting health, growth and productivity in animals. Objective: This study was undertaken to investigate the possible antioxidant activity and hepatoprotective effects of Phytocee™ Cool on carbon tetrachloride (CCl 4 ) induced oxidative stress and liver damage in rats. Materials and Methods: Animals were pretreated with Phytocee™ Cool for 10 days and were challenged with CCl 4 (1:1 v/v) in olive oil on the 10 th day. After 24 h of CCl 4 administration blood was collected and markers of hepatocellular damage aspartate aminotransferase (AST), alanine aminotransferase (ALT) were evaluated. Rats were sacrificed and oxidative stress in liver was estimated using malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase. Results: CCl 4 caused a significant increase in serum AST, ALT, hepatic MDA and GSH levels, whereas the SOD and catalase activities were decreased. Phytocee™ Cool pretreatment attenuated the MDA, AST ALT levels and increased the activities of SOD and catalase. Conclusion: Phytocee™ Cool demonstrated antioxidant potential and hepatoprotective effects and plausibly be used in the amelioration of oxidative stress.

10aAntioxidant10aCarbon tetrachloride10aOxidative stress10aPhytocee™ Cool1 aJoseph, Joshua, Allan1 aAyyappan, Usha, Parackal T1 aSasidharan, Suja, Rani1 aMutyala, Sridhar1 aGoudar, Krishnagouda, Shankargou1 aAgarwal, Amit uhttps://phcogres.com/article/2014/6/4/1041030974-8490138284