01878nas a2200205 4500008004100000245008100041210006900122260001800191300001200209490000600221520124000227653001801467653002901485653001201514653003101526653003301557653001301590100002101603856004801624 2009 eng d00aCestocidal Activity of Acacia caesia stem bark on Raillietina echinobothrida0 aCestocidal Activity of Acacia caesia stem bark on Raillietina ec cJanuary 2010  a179-1840 v13 a

The effects of the methanol extract of Acacia caesia Linnaeus (Mimosaceae) stem bark were examined on the avian gastrointestinal cestode, Raillietina echinobothrida Megnin. In vitro treatments of the cestodes with different concentrations, viz, 0.5, 1, 2, 5, 10, and 20 mg ml-1, of the plant extract indicated that the plant extract caused dose-dependent paralytic and mortality effects similar to that of albendazole, with significant mortality (P < 0.05) when compared to the control. However, the plant extract showed significant lethal effect only at the higher concentrations such as 5, 10, and 20 mg ml-1 while albendazole was effective at all concentrations tested. Scanning electron microscopy of the cestode treated with 20 mg ml-1 of the plant extract showed profound morphological alterations which were the deliberate hallmark effects of anthelmintic drugs. Devastating obliteration of tegumental surface, focal erosion and degeneration of the microtriches of the proglottids, and distortion of suckers on the scolex were clearly discernible. The plant extract thus showed profound anthelmintic effects and apparently acted trans-tegumentally to cause morphological damages.

10aAcacia caesia10aAlbendazole Anthelmintic10aCestode10aRaillietina echinobothrida10aScanning electron microscopy10aTegument1 aK., Lalchhandama uhttps://phcogres.com/article/2009/1/4/nil-3