02332nas a2200193 4500008004100000245011600041210006900157260001500226300001000241490000600251520168800257653001201945653001201957653002001969653002601989100002402015700003602039856006302075 2011 eng d00aAntihyperglycemic effect of the alcoholic seed extract of Swietenia macrophylla on streptozotocin-diabetic rats0 aAntihyperglycemic effect of the alcoholic seed extract of Swiete cApril 2011 a67-710 v33 a

Background: Streptozotocin (STZ) selectively destroys the pancreatic insulin secreting cells, leaving less active cells and resulting in a diabetic state. The present study was designed to investigate the antihyperglycemic effect of the ethanolic seed extract of Swietenia macrophylla (SME) in normal and STZ-diabetic rats. Materials and Methods: The experimental groups were rendered diabetic by intraperitoneal injection of a single dose of STZ (40 mg/kg body weight [BW]). Rats with glucose levels > 200 mg/dL were considered diabetic and were divided into 5 groups. Three groups of diabetic animals were orally administered, daily with seed extract at a dosage of 50, 100, and 200 mg/kg BW. One group of STZ rats was treated as diabetic control and the other group was orally administered 600 ΅g/kg BW glibenclamide daily. Results: Graded doses of seed extract and glibenclamide showed a significant reduction in blood glucose levels and improvement in serum insulin levels. The extract also improved body weight and promoted liver glycogen content. After treatment, hemoglobin (Hb) level increased and glycosylated Hb level significantly decreased in diabetic rats. The activities of the carbohydrate metabolic enzymes showed significant changes in the rats. Of the 3 doses, 100 mg dose showed maximum activity. Histological investigations of pancreas also supported the biochemical findings. Conclusions: Thus, our findings indicate the folklore use of the seed for diabetes and the mechanism seems to be insulin secretion.

10aGlucose10aInsulin10astrepotozotocin10aSwietenia macrophylla1 aKalaivanan, Kalpana1 aPugalendi, Kodukkur, Viswanatha uhttps://phcogres.com/article/2011/3/1/1041030974-849079119