02216nas a2200181 4500008004100000245009500041210006900136260001300205300001200218490000600230520162500236653002601861653002501887653001101912653002201923653002501945856006401970 2012 eng d00aEffect of Ethanolic Extract of Acacia Auriculiformis Leaves on Learning and Memory in Rats0 aEffect of Ethanolic Extract of Acacia Auriculiformis Leaves on L cMay,2014 a246-2500 v63 a

Background: The effects and benefits of Acacia auriculiformis on health are not well established. This study was planned to evaluate the effect of ethanolic extract of Acacia auriculiformis leaves on learning and memory in rats. Materials and Methods: Learning and memory were evaluated using passive avoidance paradigm and rewarded alternation test (T-maze) after the oral administration of two doses (200mg/kg and 400mg/kg) of ethanolic extract of Acacia auriculiformis with rivastigmine as positive control. Forty eight rats were divided into 4 groups in each study model. Estimation of brain cholinesterase activity was done to substantiate the results of the above mentioned tests. Data was analyzed using one way Analysis of Variance (ANOVA) followed by Tukey's post-hoc test using GraphPad InStat software, version 3.06. Results: The extract produced a dose-dependent improvement in the memory score namely the step through latency in passive avoidance model (P < 0.001) and the percentage of correct responses in rewarded alternation test (P < 0.05). Dose-dependent inhibition of brain cholinesterase activity (P < 0.001) was also noted. Conclusion: The acetylcholinesterase inhibiting property of Acacia auriculiformis contributes to its memory enhancing potential. Further large scale studies are required to elucidate its benefits on cognitive function. This may offer a promising new option for the treatment of dementia and other cognitive deficits.

10aAcacia auriculiformis10aAcetylcholinesterase10aMemory10aPassive Avoidance10aRewarded alternation uhttps://phcogres.com/article/2012/6/3/1041030974-8490132605