02032nas a2200253 4500008004100000245010200041210006900143260001300212300001200225490000600237520124600243653000901489653002901498653002101527653001301548653000801561100001901569700002401588700002701612700002001639700003501659700002001694856006401714 2014 eng d00aAmeliorative Effect of Matricaria chamomilla.L on Paraquat: Induced Oxidative Damage in Lung Rats0 aAmeliorative Effect of Matricaria chamomillaL on Paraquat Induce cMay,2014 a199-2030 v63 a

Background: Herbal medicines have been long used for antioxidant properties. The purpose of this study was to investigate the effect of hydroalcholic extract Matricaria chamomilla. L (M. chamomilla) against Paraquat (PQ) induced pulmonary injury in association with its antioxidant activity. Materials and Methods: Effective doses of PQ (5 mg/kg/day) and M. chamomilla (50 mg/kg/day) were administered alone or in combination for 7 days. At the end of the experiment, lung tissue of the animals was separated. The activity of enzymatic scavengers such as glutathione peroxidase (GPx) and superoxide dismutase (SOD), lipid peroxidation (LPO) and total antioxidant power (TAP) were measured. Results: In these samples, the LPO, SOD, and GPx were higher in the PQ group as compared with controls. M. chamomilla extract ameliorated LPO, SOD, GPx and increased TAP in plasma and lung tissue of PQ induced changes. Co administration of PQ with M. chamomilla improved LPO and SOD, and GPx. Conclusion: M. chamomilla as natural antioxidant may be considered beneficial for the protection oxidative lung injury in PQ poisoning.

10aLung10aMatricaria chamomilla. L10aOxidative stress10aParaquat10aRat1 aRanjbar, Akram1 aMohsenzadeh, Fariba1 aChehregani, Abdolkarim1 aKhajavi, Farzad1 aZijoud, Seyed-Mostafa, Hossini1 aGhasemi, Hassan uhttps://phcogres.com/article/2014/6/3/1041030974-8490132595