02124nas a2200229 4500008004100000245013800041210006900179260001500248300001000263490000600273520136400279653001901643653003301662653002601695653002101721100001701742700001501759700001601774700002101790700002001811856006301831 2011 eng d00aEvaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves0 aEvaluation of acute toxicity and hepatoprotective activity of th cApril 2011 a40-430 v33 a

Background: D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant. Material and Methods: The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently. Results: The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls. Conclusions: Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.

10aAcute toxicity10acarbon tetrachloride induced10aDichrostachys cinerea10aHepatoprotective1 aBabu, Suresh1 aKrishna, V1 aMaruthi, KR1 aShankarmurthy, K1 aBabu, Ramesh, K uhttps://phcogres.com/article/2011/3/1/1041030974-849079114