01720nas a2200217   4500008004100000245010100041210006900142260001800211300001000229490000600239520105200245653003601297653001401333653001001347653002101357653001401378653003001392100001501422700001701437856004801454       2009                        eng d00aModulation of Phosphatase Levels in Mice Liver by Genistein Treatment against Radiation Exposure0 aModulation of Phosphatase Levels in Mice Liver by Genistein Trea  cJanuary 2010   a72-790 v13 a<p class="rtejustify">Genistein is a soya isoflavone, which is found naturally in legumes, such as soybeans and chickpeas. The intraperitoneal administration of optimum dose (200 mg/kg body weight) of Genistein before 24 hrs and 15 minutes of irradiation (8 Gy at a dose rate of 1.02 Gy/min) increased the acid phosphatase (by 34.7 ± 12.39%) and decreased the alkaline phosphatase (by 49.59 ± 13.82%) in experimental group as compared to control group in liver of Swiss albino mice. Statistically analyzed survival data produced a dose reduction factor (DRF) = 1.24. The results indicate that Genistein against radiation effect may pave way to the formulation of medicine in radiotherapy for normal tissue and possible against radiomimetic drug induced toxicity. Present study also establishes the fact that Genistein may be used as a radioprotector before and after radiation exposure. Hence the possibility of its use as a radioprotectant and radiotherapeutic drug in accidental conditions or nuclear war conditions can not be ruled out.</p>
10aAcid and Alkaline phosphatases.10aGenistein10aLiver10aOxidative stress10aRadiation10aTyrosine kinase inhibitor1 aGaur, Ajay1 aBhatia, A.L.  uhttps://phcogres.com/article/2009/1/2/nil-3