02420nas a2200241 4500008004100000245016500041210006900206260001500275300001200290490000600302520159500308653001501903653002001918653001601938653002301954100002101977700001601998700002302014700002402037700002802061700002502089856006402114 2014 eng d00aAnti-allodynic and Anti-hyperalgesic Effects of an Ethanolic Extract and Xylopic Acid from the Fruits of Xylopia aethiopica in Murine Models of Neuropathic Pain0 aAntiallodynic and Antihyperalgesic Effects of an Ethanolic Extra cMarch,2014 a172-1790 v63 a

Background: Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including headache and neuralgia. An animal model of vincristine-induced sensory neuropathy was developed after repeated intraperitoneal injection in rats and used in the present work to study the effects of the ethanolic extract of X. aethiopica (XAE) and its diterpene xylopic acid (XA) in vincristine-induced neuropathic pain. Materials and Methods: Vincristine (0.1 mg kg -1 day -1 ) was administered during two cycles of five consecutive days to induce chemotherapy-induced neuropathic pain. Static tactile anti-allodynic, anti-hyperalgesic, and cold anti-allodynic effects of XAE (30-300 mg kg -1 ) and XA (10-100 mg kg -1 ) were assessed using Von Frey filaments of bending forces of 4, 8, and 15 g, the Randall-Selitto paw pressure test, and cold water (4.5°C), respectively. Results: Administration of vincristine caused the development of allodynia and hyperalgesia with no significant motor deficit, spontaneous pain, and foot deformity. XAE (30-300 mg kg -1 ) and XA (10-100 mg kg -1 ) exhibited anti-hyperalgesic, tactile, and cold anti-allodynic properties with XA exhibiting greater potency than XAE. Pregabalin (10-100 mg kg -1 ) used as control produced similar effect. Conclusion: These findings establish the anti-allodynic and anti-hyperalgesic effects of the ethanolic fruit XAE and its major diterpene XA in vincristine-induced neuropathtic pain.

10aPregabalin10aRandall-sellito10aVincristine10aVon Frey filaments1 aAmeyaw, Elvis, O1 aWoode, Eric1 aBoakye-Gyasi, Eric1 aAbotsi, Wonder, K.M1 aKyekyeku, James, Oppong1 aAdosraku, Reimmel, K uhttps://phcogres.com/article/2014/6/2/1041030974-8490129041