02284nas a2200229 4500008004100000245013100041210006900172260001500241300001200256490000600268520154400274653001201818653001601830653002201846653001401868653002701882100002001909700001801929700002501947700001801972856006401990 2014 eng d00aMargaritaria Discoidea (Euphorbiaceae) Stem Bark Extract Attenuates Allergy and Freund's adjuvant-induced Arthritis in Rodents0 aMargaritaria Discoidea Euphorbiaceae Stem Bark Extract Attenuate cMarch,2014 a163-1710 v63 a

Background: Various parts of Margaritaria discoidea find use in traditional medicine in the treatment of pain and oedema. This study evaluated the anti-allergic, anti-inflammatory and anti-arthritic effects of a 70% (v/v) aqueous ethanol extract of the stem bark of Margaritaria discoidea, MDE in rodents. Materials and Methods: Systemic anaphylaxis was induced by the injection of compound 48/80 into mice and their survival rate was monitored to evaluate the anti-allergic action of the extract. The effect of MDE assessed on the maximal and total oedema responses in the mouse carrageenan-induced paw oedema was used to evaluate the anti-inflammatory action of the extract while the Freund's adjuvant-induced arthritis model was employed to study the anti-arthritic effects of MDE. Results: MDE dose-dependently increased the time for compound 48/80-induced mortality in mice. MDE suppressed the mean maximal swelling and the total paw swellings induced over 6 h in the carrageenan-induced paw oedema when administered either prophylactically or therapeutically. MDE caused a reduction in serum levels of TNFα and IL-6 and significantly suppressed Freund's adjuvant-induced arthritis. Conclusion: Margaritaria discoidea suppresses allergy and exhibits anti-inflammatory activity in mice. In addition it attenuates Freund's adjuvant-induced arthritis through a reduction in serum levels of TNFα and IL-6 in rats.

10aAllergy10aAnaphylaxis10aAnti-inflammatory10aArthritis10aMargaritaria discoidea1 aObiri, David, D1 aOsafo, Newman1 aOppong-Sarfo, Joshua1 aPrah, Jude, K uhttps://phcogres.com/article/2014/6/2/1041030974-8490129039