02589nas a2200265 4500008004100000245009400041210006900135260001500204300001000219490000600229520179100235653001002026653002202036653003102058653004202089653001002131653001402141100001502155700001802170700001702188700001502205700001402220700002602234856006302260 2011 eng d00aIn vitro antiproliferative activity of Annona reticulata roots on human cancer cell lines0 aIn vitro antiproliferative activity of Annona reticulata roots o cApril 2011 a09-120 v33 a

Background: The phytochemical and pharmacological activities of Annona reticulata components suggest a wide range of clinical application in lieu of cancer chemotherapy. Materials and Methods: Ethanol and aqueous extracts of roots of Annona reticulata Linn were studied for their in vitro antiproliferative activity on A-549 (human lung carcinoma), K-562 (human chronic myelogenous leukemia bone marrow), HeLa (human cervix) and MDA-MB (human adenocarcinoma mammary gland) cancer cell lines by MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] colorimetric assay. Results: The ethanol extract exhibited a prominent inhibitory effect against A-549, K-562, HeLa and MDA-MB human cancer cell lines at a concentration range between 10 and 40 μg/ml, whereas the aqueous extract showed a lower activity at the same concentration. Simultaneously, the effect of the ethanol extract toward the inhibition of Vero cell line proliferation was lower in comparison with the cancer cell lines. Conclusion: The significant antiproliferative activity of the ethanol extract of Annona reticulata roots against A-549, K-562, HeLa and MDA-MB human cancer cell lines may be attributed toward the collective presence of acetogenins, alkaloids and lower inhibitory effect on Vero cell line, which suggests Annona reticulata be used as a chemopreventive agent in cancer therapy.

10aA-54910aAnnona reticulata10aAntiproliferative activity10aHeLaand MDA-MBhuman cancer cell lines10aK-56210aMTT assay1 aSuresh, HM1 aShivakumar, B1 aHemalatha, K1 aHeroor, SS1 aHugar, DS1 aRao, K.R.S, Sambasiva uhttps://phcogres.com/article/2011/3/1/1041030974-849079109