02261nas a2200229 4500008004100000245013800041210006900179260001500248300001000263490000600273520153300279653001501812653001601827653002701843100001701870700001701887700001301904700001701917700001601934700001801950856006301968 2011 eng d00aAnti-ulcerogenic and in vitro antioxidant activities of Lagenaria breviflora (LB) whole fruit ethanolic extract in laboratory animals0 aAntiulcerogenic and in vitro antioxidant activities of Lagenaria cApril 2011 a02-080 v33 a

Background: The present study was undertaken to evaluate the anti-ulcer and antioxidant activities of the ethanol extract of Lagenaria breviflora (EELB) whole fruit in laboratory rats. Methods: The anti-ulcer property of the ethanolic extract of the whole fruit of Lagenaria breviflora (LB) was assessed using the cold-restraint stress-induced (CRU) gastric ulcer, pyloric ligation-induced (PL) gastric ulcer, aspirin-induced (ASP) gastric ulcer and alcohol-induced (AL) gastric ulcer models. The scavenging activity of the LB extract was examined with 1, 1-diphenyl-2-picryl-hydrazyl (DPPH), Nitric oxide, Hydroxyl radical and Superoxide anion scavenging models. Results: EELB (50, 100, 150 and 200 mg/kg, b.w.) protected against the CRU gastric ulcer dose dependently. Similarly, 150 mg/kg b.w. of the LB extract protected against the PL gastric ulcer, ASP gastric ulcer and AL gastric ulcer and was comparable to omeprazole (10 mg/kg b.w.) or Suscralfate (500 mg/kg b.w.), respectively. The in vitro antioxidant activity of LB was demonstrated by its ability to quench free radicals generated by nitric oxide and superoxide anion with a concomitant scavenging potential against DPPH-induced radical formation. Conclusion: Taken together, the study showed that the whole fruit extract possess potent anti-ulcer and antioxidant activities.

10aAnti-ulcer10aAntioxidant10afree radical scavenger1 aOnasanwo, SA1 aSingh, Neetu1 aSaba, AB1 aOyagbemi, AA1 aOridupa, OA1 aPalit, Gautam uhttps://phcogres.com/article/2011/3/1/1041030974-849079108