01961nas a2200217 4500008004100000245009300041210006900134260001500203300001200218490000600230520128700236653002301523653001301546653001301559653001401572653002301586653002601609100002301635700002101658856006401679 2014 eng d00aEvaluation of Antiepileptic Activity of Chloroform Extract of Acalypha Fruticosa in Mice0 aEvaluation of Antiepileptic Activity of Chloroform Extract of Ac cMarch,2014 a108-1120 v63 a

Aim: The aim of the present study is to evaluate the antiepileptic activity of chloroform extract of aerial parts of Acalypha fruticosa in mice. Materials and Methods: The antiepileptic activity of chloroform extract of A. fruticosa at the doses of 30, 100 and 300 mg/kg, p.o. was evaluated by maximum electroshock (MES), pentylenetetrazole (PTZ) and isoniazid (INH)-induced convulsions in mice. Statistical analysis was carried out by one-way analysis of variance followed by Dunnett's test. Results: In MES method, the chloroform extract significantly protected the mice from convulsions induced by electroshock method in a dose-dependent manner and exhibited more activity at the dose of 300 mg/kg when compared with diazepam treated animals. In PTZ method, the extract inhibited convulsions in mice potent than phenobarbitone sodium. In INH method, it delayed the latency of convulsions in mice in a dose-dependent manner but failed to protect the mice against mortality. Conclusion: The chloroform extract exhibited significant and dose-dependent antiepileptic activity, which may be due to the presence of antioxidant principles like flavanoids.

10aAcalypha fruticosa10aDiazepam10aEpilepsy10aIsoniazid10aPentylenetetrazole10aPhenobarbitone sodium1 aGovindu, Sumalatha1 aAdikay, Sreedevi uhttps://phcogres.com/article/2014/6/2/1041030974-8490128970