02842nas a2200205 4500008004100000245017100041210006900212260001800281300001100299490000600310520209000316653002202406653003402428653002002462653002302482100003202505700001802537700001702555856006402572 2014 eng d00aSynergistic Effect of the Hydroalcoholic Extract from Lepidium meyenii (Brassicaceae) and Fagara tessmannii (Rutaceae) on Male Sexual Organs and Hormone Level in Rats0 aSynergistic Effect of the Hydroalcoholic Extract from Lepidium m cDecember,2013 a 80-860 v63 a

Background: Lepidium meyenii is a plant, which has been used in folk medicine to treat infertility and to increase sexual desire. However, few reports have investigated the administration of this plant with other plants having the same properties. Objective: The present investigation was designed to evaluate whether the combination of Lepidium meyenii and Fagara tessmannii can improve spermatogenesis and testosterone level in rats. Materials and Method: Twenty male rats were treated daily for 2 weeks with the hydroalcoholic extract of Fagara tessmannii and Lepidium meyenii (Fag + MN) as follow: (vehicle), (0.01 g + 0.5 mg), (0.1 g + 5 mg) and (1 g+ 50 mg)/kg BW. Results: At doses Fag 0.01 g/MN 0.5 mg and Fag 0.1 g/MN 5 mg, the weight of seminal vesicle, prostate, and testis significantly decreased (P < 0.05) while at dose Fag 1 g/MN 50 mg, the weight of epididymis and testis significantly increased (P < 0.05) when compared to the control. We noticed a significant increase of the number of spermatids/test (P < 0.05), epididymis sperm count (P < 0.05), and DSP/test of the rats at dose Fag 1 g/MN 50 mg while at dose Fag 0.01 g/MN 0.5 mg and Fag 0.1 g/MN 5 mg, sperm count was reduced in male organs, particularly in vas deferens (P < 0.05) and epididymis (P < 0.001). The serum testosterone concentration significantly decreased (P < 0.05) at lowest dose Fag 0.01 g/MN 0.5 mg. However, at highest dose Fag 1 g/MN 50 mg, the serum testosterone concentration increased significantly (P < 0.05). The length of stage VII-VIII and IX-I of the seminiferous tubule significantly (P < 0.05) increased while the length of stage II-VI significantly (P < 0.05) decreased. Conclusion: The results indicated that the combination of Lepidium meyenii (Black Maca) with Fagara tessmannii can improve male reproductive organs activities.

10aFagara tessmannii10aLepidium meyenii (Maca Negro)10aSpermatogenesis10aTestosterone level1 aLembè, Dieudonné, Massoma1 aGasco, Manuel1 aGonzales, GF uhttps://phcogres.com/article/2014/6/1/1041030974-8490121451