02241nas a2200193 4500008004100000245011900041210006900160260001800229300001000247490000600257520159700263100002401860700001501884700002101899700002501920700002101945700001701966856006401983 2014 eng d00aThe Efficacy of Ginger Added to Ondansetron for Preventing Postoperative Nausea and Vomiting in Ambulatory Surgery0 aEfficacy of Ginger Added to Ondansetron for Preventing Postopera cDecember,2013 a52-570 v63 a

Background: Post-operative nausea and vomiting (PONV) frequently hampers implementation of ambulatory surgery in spite of so many costly antiemetic drugs and regimens. Objective: The study was carried out to compare the effi cacy of ginger (Zingiber offi cinale) added to Ondansetron in preventing PONV after ambulatory surgery. Materials and Methods: It was a prospective, double blinded, and randomized controlled study. From March 2008 to July 2010, 100 adult patients of either sex, aged 20-45, of ASA physical status I and II, scheduled for day care surgery, were randomly allocated into Group A[(n = 50) receiving (IV) Ondansetron (4 mg) and two capsules of placebo] and Group B[(n = 50) receiving IV Ondansetron (4 mg) and two capsules of ginger] simultaneously one hour prior to induction of general anaesthesia (GA) in a double-blind manner. One ginger capsule contains 0.5 gm of ginger powder. Episodes of PONV were noted at 0.5h, 1h, 2h, 4h, 6h, 12h and 18h post- operatively. Statistical Analysis and Results: Statistically signifi cant difference between groups A and B (P < 0.05), was found showing that ginger ondansetron combination was superior to plain Ondansetron as antiemetic regimen for both regarding frequency and severity. Conclusion: Prophylactic administration of ginger and ondansetron signifi cantly reduced the incidence of postoperative nausea and vomiting compared to ondansetron alone in patients undergoing day care surgery under general anaesthesia.

1 aMandal, Pragnadyuti1 aDas, Anjan1 aMajumdar, Saikat1 aBhattacharyya, Tapas1 aMitra, Tapobrata1 aKundu, Ratul uhttps://phcogres.com/article/2014/6/1/1041030974-8490122918